Product nameAnti-IL23 antibodySee all IL23 products （5） ...
- Description Rabbit polyclonal to IL23
- Tested applicationsWB, IHC-P, ICCmore details
- Cross reactivity Reacts with: Mouse, Human
- Immunogen
A 16 amino acid synthetic peptide conjugated to KLH, corresponding to the C-terminus of Human IL23.
- Positive controlHuman Kidney, Mouse brain, Mouse kidney and Mouse liver tissues
Properties
- FormLiquid
- Storage instructionsStore at +4°C.
- Storage bufferPreservative: 0.02% Sodium azide
Constituent: 99% PBS - Concentration50 µg at 1 mg/ml
- PurityImmunogen affinity purified
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
- Cancer
- Tumor immunology
- Cytokines
- Interleukins
- Immunology
- Innate Immunity
- Cytokines
- Interleukins
Applications
Our Abpromise guarantee covers the use of ab115759 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| WB | WB: Use a concentration of 2 - 4 µg/ml. Predicted molecular weight: 21 kDa. |
| IHC-P | IHC-P: Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
| ICC | ICC: Use at an assay dependent dilution. |
Target
- FunctionAssociates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
- Tissue specificitySecreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells （at protein level）.
- Sequence similaritiesBelongs to the IL-6 superfamily.
- Developmental stageExpressed by newborns dendritic cells.
- Cellular localizationSecreted. Secreted upon association with IL12B.
- Database links
- Entrez Gene: 51561 Human
- Entrez Gene: 83430 Mouse
- Entrez Gene: 83430 Mouse
- Omim: 605580 Human
- SwissProt: Q9NPF7 Human
- SwissProt: Q9EQ14 Mouse
- SwissProt: Q9EQ14 Mouse
- Unigene: 98309 Human
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Information by UniProt
- Alternative names
- IL 23 antibodyIL 23A antibodyIL-23 subunit alpha antibody
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Anti-IL23 antibody images
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Immunohistochemistry （Formalin/PFA-fixed paraffin-embedded sections） - Anti-IL23 antibody （ab115759）Human Kidney （formalin-fixed, paraffin-embedded） stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. -
Immunohistochemistry （Formalin/PFA-fixed paraffin-embedded sections） - Anti-IL23 antibody （ab115759）Mouse Brain （formalin-fixed, paraffin-embedded） stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. -
Immunohistochemistry （Formalin/PFA-fixed paraffin-embedded sections） - Anti-IL23 antibody （ab115759）Mouse Kidney （formalin-fixed, paraffin-embedded） stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. -
Immunohistochemistry （Formalin/PFA-fixed paraffin-embedded sections） - Anti-IL23 antibody （ab115759）Mouse Liver （formalin-fixed, paraffin-embedded） stained with ab115759 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
